Juvenile xanthogranuloma
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Ang Juvenile xanthogranuloma (JXG) ay isang medyo karaniwang kondisyon at ang pinakamadalas na uri ng non-Langerhans cell histiocytic disorder sa mga bata. Sa humigit-kumulang 75% ng mga kaso, ang mga sugat na ito ay lilitaw sa loob ng unang taon ng buhay, at higit sa 15-20% ng mga pasyente ay may mga ito mula sa kapanganakan. Bagama't bihira sa mga nasa hustong gulang, kadalasang nangyayari ang JXG sa mga taong nasa huling bahagi ng twenties hanggang thirties, at karamihan sa mga pasyenteng nasa hustong gulang ay may isang sugat lamang. Sa klinikal na paraan, lumilitaw ito bilang isa o maramihang dilaw-kahel-kayumangging mga bukol o bukol, pangunahin sa mukha, leeg, at itaas na katawan. Ang mga sugat sa bibig ay hindi pangkaraniwan ngunit maaaring lumitaw bilang isang dilaw na bukol sa mga gilid ng dila o sa ibang lugar sa bibig, na posibleng humantong sa mga ulser at pagdurugo. Ang mga sugat sa balat ay kadalasang hindi nagdudulot ng mga sintomas at malamang na kusang nawawala sa loob ng ilang taon. Bagama't bihira, ang ocular involvement ay ang pinakakaraniwang isyu sa kabila ng balat, na sinusundan ng lung involvement. Ang Ocular JXG ay karaniwang nakakaapekto lamang sa isang mata at nangyayari sa mas mababa sa 0. 5 % ng mga pasyente, bagaman humigit-kumulang 40% ng mga may ocular involvement ay mayroon ding maraming sugat sa balat kapag na-diagnose.
Juvenile xanthogranuloma (JXG) is a relatively common entity and is the most common form of non-Langerhans cell histiocytic disorder of childhood., It is estimated that in 75% of cases, lesions appear during the first year of life, with >15-20% of patients having lesions at birth. JXG is rare in adults, with a peak incidence in the late twenties to thirties. The majority of adult patients have solitary lesions. Typically, the clinical presentation consists of solitary or multiple yellow-orange-brown firm papules or nodules. The most common locations are the face, neck, and upper torso. Oral lesions are rare and often occur as a yellow nodule on the lateral aspects of the tongue. Oral lesions can also arise on the gingival, buccal mucosa, and midline hard palate and may ulcerate and bleed. Cutaneous lesions are usually asymptomatic, and most lesions spontaneously involute over the course of several years. Although occurring rarely, ocular involvement is the most common extracutaneous site involved, followed by the lungs. Ocular JXG is nearly always unilateral and develops in less than 0.5% of patients. Approximately 40% of patients with ocular JXG, however, have multiple cutaneous lesions at the time of diagnosis.
Juvenile xanthogranuloma (JXG) is a relatively common entity and is the most common form of non-Langerhans cell histiocytic disorder of childhood., It is estimated that in 75% of cases, lesions appear during the first year of life, with >15-20% of patients having lesions at birth. JXG is rare in adults, with a peak incidence in the late twenties to thirties. The majority of adult patients have solitary lesions. Typically, the clinical presentation consists of solitary or multiple yellow-orange-brown firm papules or nodules. The most common locations are the face, neck, and upper torso. Oral lesions are rare and often occur as a yellow nodule on the lateral aspects of the tongue. Oral lesions can also arise on the gingival, buccal mucosa, and midline hard palate and may ulcerate and bleed. Cutaneous lesions are usually asymptomatic, and most lesions spontaneously involute over the course of several years. Although occurring rarely, ocular involvement is the most common extracutaneous site involved, followed by the lungs. Ocular JXG is nearly always unilateral and develops in less than 0.5% of patients. Approximately 40% of patients with ocular JXG, however, have multiple cutaneous lesions at the time of diagnosis.
Ang Juvenile xanthogranulomas (JXGs) ay hindi pangkaraniwan, benign na sakit na bahagi ng mas malaking kategorya ng non-Langerhans cell histiocytoses. Karaniwang lumalabas ang mga ito bilang isa o higit pang pula o madilaw na bukol, kadalasang makikita sa ulo o leeg. Karamihan sa mga JXG ay nabubuo sa kapanganakan o sa loob ng unang taon ng buhay. Bagama't hindi karaniwan, kung minsan ay maaaring makaapekto ang mga ito sa mga lugar na lampas sa balat, na ang pagkakasangkot sa mata ay isang bagay na dapat bantayan ayon sa umiiral na literatura. Sa pangkalahatan, ang mga JXG sa balat ay kusang nawawala at karaniwang hindi nangangailangan ng paggamot.
Juvenile xanthogranulomas (JXGs) are uncommon, benign diseases that are part of a larger category of non-Langerhans cell histiocytoses. They typically show up as one or more red or yellowish lumps, often found on the head or neck. Most JXGs develop either at birth or within the first year of life. While it's unusual, sometimes they can affect areas beyond the skin, with eye involvement being something to watch for according to existing literature. Generally, JXGs on the skin go away on their own and typically don't need treatment.
Juvenile xanthogranulomas (JXGs) are uncommon, benign diseases that are part of a larger category of non-Langerhans cell histiocytoses. They typically show up as one or more red or yellowish lumps, often found on the head or neck. Most JXGs develop either at birth or within the first year of life. While it's unusual, sometimes they can affect areas beyond the skin, with eye involvement being something to watch for according to existing literature. Generally, JXGs on the skin go away on their own and typically don't need treatment.
Ang ocular lesion ay nagpapakita sa hanggang 10% ng mga taong may JXG at maaaring makaapekto sa kanilang paningin. Bagama't ang mga sugat sa balat ay karaniwang kusang nawawala, ang mga sugat sa mata ay bihirang bumubuti nang kusang at nangangailangan ng paggamot.